In this work, we present the outlines of the periodic homogenization of the diffusion equation with chemical reaction at the interface, for different orders of magnitude of the Damkohler number. For large values of the Damkohler number, a non-classical homogenized model is obtained, where the homogenized diffusion tensor is strongly coupled with the chemical reaction rate. This homogenized model is particularly well adapted to describe, at the macroscopic level, diffusion with strong chemical reactions at the pore interfaces. The aim of this article is to highlight the transition between different regimes of diffusion-reaction according to the order of magnitude of the Damkohler number. In the last part of this work, we first consider a simple analytical example between two parallel plates, to understand the transition between the different possible regimes of diffusion-reaction. Finally, numerical simulations are performed on more complex two-dimensional elementary cells.